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REVIEW ARTICLE
Year : 2014  |  Volume : 51  |  Issue : 2  |  Page : 75-81

Revisiting the multigene families: Plasmodium var and vir genes


1 National Institute of Malaria Research (ICMR), Dwarka, New Delhi, India
2 Department of Biotechnology, Kumaun University, Nainital, Uttarakhand, India

Correspondence Address:
Vineeta Singh
Scientist ‘C’, National Institute of Malaria Research (ICMR), Sector–8, Dwarka, New Delhi–110 077
India
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Source of Support: None, Conflict of Interest: None


PMID: 24947212

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Malaria is an infectious disease that is widespread in tropical and subtropical regions. The malaria parasite is able to skip the host immunity and thus maintains not only persistent but also repeated infections. There are a number of multigene families in Plasmodium that code for the variant antigens and are targets for protective immunity. In this article, we summarize the virulence genes of P. falciparum (var genes) and P. vivax (vir genes) which play key roles in disease pathogenesis by evading elimination by the host immune system. These genes occurring within the parasite population are mostly present in the subtelomeric regions of the chromosome.


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