|LETTER TO THE EDITOR
|Year : 2018 | Volume
| Issue : 3 | Page : 245
Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship
Sora Yasri1, Viroj Wiwanitkit2
1 KMT Primary Care Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, China
|Date of Web Publication||4-Jan-2019|
KMT Primary Care Center, Bangkok
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Yasri S, Wiwanitkit V. Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship. J Vector Borne Dis 2018;55:245
|How to cite this URL:|
Yasri S, Wiwanitkit V. Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship. J Vector Borne Dis [serial online] 2018 [cited 2019 May 27];55:245. Available from: http://www.jvbd.org/text.asp?2018/55/3/245/249485
The liver fluke infestation is very common in tropical Indochina. In Thailand, >3,000,000 local people are infested and have the risk for its important complication, biliary tract cancer. Of interest, in the same area, an extremely high prevalence of tropical vector-borne disease (dengue) is also observed. The dengue infection in cases with underlying liver fluke infestation is also possible. There is limited knowledge on this issue. Here, the authors would like to draw attention on the observation on protein tyrosine kinase seen in both liver fluke infestation (opisthorchiasis) and dengue. In opisthorchiasis, an increased level of protein tyrosine kinase is observed, and there is a report showing that inhibition of the protein tyrosine kinase can result in suppression of dengue virus in animal model, hence the protein kinase blocking becomes the focus in dengue drug development. Based on these data, it might be assumed that there is a possible interrelationship and concurrent role of protein tyrosine kinase in pathophysiology of both opisthorchiasis and dengue. The dengue infection in case with underlying opisthorchiasis might be more serious.
This finding is an important correlation for areas where both dengue and liver fluke infections are common such as in southeast Asian countries (Laos, Cambodia, Thailand and Vietnam).
Conflict of interest: None.
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