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Table of Contents
Year : 2018  |  Volume : 55  |  Issue : 3  |  Page : 245

Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship

1 KMT Primary Care Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, China

Date of Web Publication4-Jan-2019

Correspondence Address:
Sora Yasri
KMT Primary Care Center, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-9062.249485

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How to cite this article:
Yasri S, Wiwanitkit V. Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship. J Vector Borne Dis 2018;55:245

How to cite this URL:
Yasri S, Wiwanitkit V. Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship. J Vector Borne Dis [serial online] 2018 [cited 2022 Oct 5];55:245. Available from: https://www.jvbd.org/text.asp?2018/55/3/245/249485

Dear Editor,

The liver fluke infestation is very common in tropical Indochina. In Thailand, >3,000,000 local people are infested and have the risk for its important complication, biliary tract cancer[1]. Of interest, in the same area, an extremely high prevalence of tropical vector-borne disease (dengue) is also observed[2]. The dengue infection in cases with underlying liver fluke infestation is also possible. There is limited knowledge on this issue. Here, the authors would like to draw attention on the observation on protein tyrosine kinase seen in both liver fluke infestation (opisthorchiasis) and dengue. In opisthorchiasis, an increased level of protein tyrosine kinase is observed[3], and there is a report showing that inhibition of the protein tyrosine kinase can result in suppression of dengue virus in animal model, hence the protein kinase blocking becomes the focus in dengue drug development[4]. Based on these data, it might be assumed that there is a possible interrelationship and concurrent role of protein tyrosine kinase in pathophysiology of both opisthorchiasis and dengue. The dengue infection in case with underlying opisthorchiasis might be more serious.

This finding is an important correlation for areas where both dengue and liver fluke infections are common such as in southeast Asian countries (Laos, Cambodia, Thailand and Vietnam).

Conflict of interest: None.

  References Top

Echaubard P, Sripa B, Mallory FF, Wilcox BA. The role of evolutionary biology in research and control of liver flukes in Southeast Asia. Infect Genet Evol 2016; 43: 381–97.  Back to cited text no. 1
Limkittikul K, Brett J, L'Azou M. Epidemiological trends of dengue disease in Thailand (2000–2011): A systematic literature review. PLoS Negl Trop Dis 2014; 8(11): e3241.  Back to cited text no. 2
Khoontawad J, Laothong U, Roytrakul S, Pinlaor P, Mulvenna J, Wongkham C, et al. Proteomic identification of plasma protein tyrosine phosphatase alpha and fibronectin associated with liver fluke, Opisthorchis viverrini, infection. PLoS One 2012; 7(9): e45460.  Back to cited text no. 3
Limjindaporn T, Panaampon J, Malakar S, Noisakran S, Yenchitsomanus PT. Tyrosine kinase/phosphatase inhibitors decrease dengue virus production in HepG2 cells. Biochem Biophys Res Commun 2017; 483(1): 58–63.  Back to cited text no. 4


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