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ORIGINAL ARTICLE
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Severity of dengue illness and presence of anti DV IgG in serum of laboratory confirmed dengue cases


 Department of Microbiology, King George's Medical University, Lucknow-226003, India

Correspondence Address:
Amita Jain,
Department of Microbiology, King George's Medical University, Lucknow-226003
India
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Source of Support: None, Conflict of Interest: None

Background & objective: Presence of dengue is reported from India since 1960s. Secondary dengue infection may be more severe than primary, hence, distinction between primary and secondary dengue is essential. One way to detect secondary dengue is demonstration of anti DV IgG in patients' serum. In this study we explored the association of dengue severity with anti DV IgG. Methods: Laboratory confirmed cases of dengue (positive for anti DV IgM/ NS-1 Antigen/ DV -RNA), presenting to the hospital within 7 days of illness, were consecutively enrolled for a period of one month (1st-30th September, 2018) and were tested for anti DV IgG in their serum. All PCR positive samples were serotyped. Cases positive for anti-dengue IgG were labeled as secondary cases. Clinical details were collected to assess the severity of illness. Association of dengue severity with anti DV IgG positivity was calculated. Results: Of all the 128 dengue positive cases, 89 (69.5%) were anti DV IgM positive, 72 (56.3%) were Dengue NS-1 positives and 37 (28.9%) were DV-RNA positive. Only 39 (30.5%) cases were having detectable anti-dengue IgG in their serum (secondary dengue). Anti-dengue IgM positivity was significantly higher in secondary dengue cases. No association of anti DV IgG positivity was seen with severity of dengue illness. Interpretation & conclusion: No association of IgG positivity with severity of illness was seen. D4 serotype is first time reported from Uttar Pradesh, India


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    -  Jain A
    -  Khan DN
    -  Prakash O
    -  Shukla S
    -  Prakash S
    -  Verma AK
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