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  Indian J Med Microbiol
 

Figure 5: Malaria infection disturbs spleen function and causes splenomegaly. The parasite propagation within blood induces RBC lysis and accumulation of toxic by-products. The enhanced haemolysis, RBC clearance, red pulp macrophage activation, inflammation and oxidative damages together lead to the splenomegaly in malaria infected host.

Figure 5: Malaria infection disturbs spleen function and causes splenomegaly. The parasite propagation within blood induces RBC lysis and accumulation of toxic by-products. The enhanced haemolysis, RBC clearance, red pulp macrophage activation, inflammation and oxidative damages together lead to the splenomegaly in malaria infected host.